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Diseases caused by asbestos: an overview

The ‘killer asbestos’ has been talked about since at least 1981, when the first lawsuit was brought over the substance’s high toxicity. But what diseases can it cause, and what do they involve?

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Among the various diseases caused by environmental exposure to different substances, exposure to asbestos is certainly of great importance: a substance that has (unfortunately) made the headlines for several decades (at least since 1981, when about 80 workers brought a case against the Eternit factory and against Inail to have the damage caused by the mineral recognised).
In this article we look at which diseases exposure to asbestos can cause and what they involve.

What is asbestos?

Asbestos is a naturally occurring fibrous material derived from silicates. It was long used both in construction and in the production of textiles, before its high carcinogenicity was discovered. Inhaling asbestos fibres causes lung cancer, cancer of the pleura (mesothelioma), asbestosis, pleural effusions and thickening of the pleura.

Asbestosis

Asbestosis is a disease caused by asbestos that is more frequent than cancer. It results from inhaling toxic and irritant substances and causes interstitial pulmonary fibrosis, that is, the replacement of normal, functioning tissue with fibrous tissue, which is harder and non-functional, and is found, for example, in scars. This happens because when a toxic and irritant substance is inhaled, the immune cells in the lungs try to fight and eliminate it, increasing inflammation and oxidative damage and thereby causing the deposition of new tissue, which is first collagen and then fibrotic tissue.

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The symptoms of this condition are mainly a dry cough, that is, without mucus, breathing difficulties (dyspnoea) and general tiredness. Since the symptoms are very common, exposure in the workplace must be taken into account in the diagnosis.

Mesothelioma

A much more serious consequence of exposure to asbestos is mesothelioma, that is, cancer of the pleura of the lungs. The pleurae are two layers of tissue that surround the lungs and allow them to expand freely inside the rib cage, to stay in place, and to maintain the right pressure and insulation.
The neoplasm grows inside the pleural cavity, that is, the space between these two layers, and can spread throughout the body. Exposure to asbestos carries a risk of about 10% of developing mesothelioma; as is well known, it does not appear immediately, and it takes about 25-30 years to develop. The symptoms are chest pain and breathing difficulties. Unfortunately, the prognosis for this cancer is very poor, as it is incurable. Average survival is 9-12 months.

In addition to these two diseases, exposure to asbestos can cause pleural effusions, that is, the leakage of fluid into the pleural cavity, even years later. Besides the effusion, non-neoplastic plaques may be present.

Sources: MSD manuals.

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